An anesthetic epidural blockade with lidocaine completely eliminates spontaneous pain and tender points and/or myofascial trigger points (MTPs) in FM patients, suggesting the importance of peripheral nociceptive inputs in FM. Increasing evidence suggests that nociceptive inputs from muscle tissues and myofascial trigger points (MTPs) in particular are important in the initiation and/or maintenance of FM pain and central sensitization. The widespread pain, which constitutes the overall spontaneous pain pattern in FM, is not uniformly distributed all over the body. A defining characteristic for fibromyalgia (FM) is chronic widespread pain of musculoskeletal origin.
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